Refractory (non-reversible) asthma is a type of asthma that does not respond to usual asthma medications. In an asthma attack, bronchial airways tighten up and swell. Medications can usually reverse this, opening up the airways and returning them to how they were before the asthma attack. In refractory asthma, medications cannot reverse the tightening and swelling of the airways.

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